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Analysis of Mutant Phenotypes and Splicing Defects Demonstrates Functional Collaboration between the Large and Small Subunits of the Essential Splicing Factor U2AF In Vivo
The heterodimeric splicing factor U2AF plays an important role in 3′ splice site selection, but the division of labor between the two subunits in vivo remains unclear. In vitro assays led to the proposal that the human large subunit recognizes 3′ splice sites with extensive polypyrimidine tracts ind...
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| Published in: | Mol Biol Cell |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Cell Biology
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545896/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15548596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E04-09-0768 |
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