Analysis of Mutant Phenotypes and Splicing Defects Demonstrates Functional Collaboration between the Large and Small Subunits of the Essential Splicing Factor U2AF In Vivo

The heterodimeric splicing factor U2AF plays an important role in 3′ splice site selection, but the division of labor between the two subunits in vivo remains unclear. In vitro assays led to the proposal that the human large subunit recognizes 3′ splice sites with extensive polypyrimidine tracts ind...

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Udgivet i:Mol Biol Cell
Main Authors: Webb, Christopher J., Lakhe-Reddy, Sujata, Romfo, Charles M., Wise, Jo Ann
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Cell Biology 2005
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545896/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15548596/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E04-09-0768
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