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High incidence of proviral integrations in the Hoxa locus in a new model of E2a–PBX1-induced B-cell leukemia
Relevant mouse models of E2a–PBX1-induced pre-B cell leukemia are still elusive. We now report the generation of a pre-B leukemia model using E2a–PBX1 transgenic mice, which lack mature and precursor T-cells as a result of engineered loss of CD3ε expression (CD3ε(–/–)). Using insertional mutagenesis...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545883/ https://ncbi.nlm.nih.gov/pubmed/15655112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1268505 |
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