Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes

In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase onset until chromosomes align. Here we show that depletion of Mad2 in meiosis I mouse oocytes induced an increased incidence of aneuploidy. Proteolysis of cyclin B and securin commenced earlier in Mad2-depleted oo...

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Bibliografiske detaljer
Main Authors: Homer, Hayden A., McDougall, Alex, Levasseur, Mark, Yallop, Katie, Murdoch, Alison P., Herbert, Mary
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2005
Fag:
Research Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545877/
https://ncbi.nlm.nih.gov/pubmed/15655110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328105
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