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Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization
Wnt/β-catenin signaling is activated when extracellular Wnt ligands bind Frizzled (FZD) receptors at the cell membrane. Wnts bind FZD cysteine-rich domains (CRDs) with high affinity through a palmitoylated N-terminal “thumb” and a disulfide-stabilized C-terminal “index finger,” yet how these binding...
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| Veröffentlicht in: | Genes Dev |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5458758/ https://ncbi.nlm.nih.gov/pubmed/28546512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.298331.117 |
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