Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

Wnt/β-catenin signaling is activated when extracellular Wnt ligands bind Frizzled (FZD) receptors at the cell membrane. Wnts bind FZD cysteine-rich domains (CRDs) with high affinity through a palmitoylated N-terminal “thumb” and a disulfide-stabilized C-terminal “index finger,” yet how these binding...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: DeBruine, Zachary J., Ke, Jiyuan, Harikumar, Kaleeckal G., Gu, Xin, Borowsky, Peter, Williams, Bart O., Xu, Wenqing, Miller, Laurence J., Xu, H. Eric, Melcher, Karsten
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458758/
https://ncbi.nlm.nih.gov/pubmed/28546512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.298331.117
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