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The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition

Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological, molecular and clinical presentation. However, metabolic signatures specific to individual NSCLC subtypes remain unknown. Here, we per...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Goodwin, Justin, Neugent, Michael L., Lee, Shin Yup, Choe, Joshua H., Choi, Hyunsung, Jenkins, Dana M. R., Ruthenborg, Robin J., Robinson, Maddox W., Jeong, Ji Yun, Wake, Masaki, Abe, Hajime, Takeda, Norihiko, Endo, Hiroko, Inoue, Masahiro, Xuan, Zhenyu, Yoo, Hyuntae, Chen, Min, Ahn, Jung-Mo, Minna, John D., Helke, Kristi L., Singh, Pankaj K., Shackelford, David B., Kim, Jung-whan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458561/
https://ncbi.nlm.nih.gov/pubmed/28548087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15503
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