Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy

Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL(eff)) responses. Conversely, the induction of protective tumour-specific CTL(eff) and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Kallert, Sandra M., Darbre, Stephanie, Bonilla, Weldy V., Kreutzfeldt, Mario, Page, Nicolas, Müller, Philipp, Kreuzaler, Matthias, Lu, Min, Favre, Stéphanie, Kreppel, Florian, Löhning, Max, Luther, Sanjiv A., Zippelius, Alfred, Merkler, Doron, Pinschewer, Daniel D.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458557/
https://ncbi.nlm.nih.gov/pubmed/28548102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15327
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