Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy

Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL(eff)) responses. Conversely, the induction of protective tumour-specific CTL(eff) and their recruitment into the tumour remain challenging tasks. Here we show that lymphocytic choriomeningitis virus (LCMV...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kallert, Sandra M., Darbre, Stephanie, Bonilla, Weldy V., Kreutzfeldt, Mario, Page, Nicolas, Müller, Philipp, Kreuzaler, Matthias, Lu, Min, Favre, Stéphanie, Kreppel, Florian, Löhning, Max, Luther, Sanjiv A., Zippelius, Alfred, Merkler, Doron, Pinschewer, Daniel D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458557/
https://ncbi.nlm.nih.gov/pubmed/28548102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15327
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