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Tailing and degradation of Argonaute-bound small RNAs protect the genome from uncontrolled RNAi

RNAi is a conserved mechanism in which small RNAs induce silencing of complementary targets. How Argonaute-bound small RNAs are targeted for degradation is not well understood. We show that the adenyl-transferase Cid14, a member of the TRAMP complex, and the uridyl-transferase Cid16 add non-template...

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Publicat a:Nat Commun
Autors principals: Pisacane, Paola, Halic, Mario
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458512/
https://ncbi.nlm.nih.gov/pubmed/28541282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15332
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