Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis

Nesprins-1 and -2 are highly expressed in skeletal and cardiac muscle and together with SUN (Sad1p/UNC84)-domain containing proteins and lamin A/C form the LInker of Nucleoskeleton-and-Cytoskeleton (LINC) bridging complex at the nuclear envelope (NE). Mutations in nesprin-1/2 have previously been fo...

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Publicado no:Hum Mol Genet
Main Authors: Zhou, Can, Li, Chen, Zhou, Bin, Sun, Huaqin, Koullourou, Victoria, Holt, Ian, Puckelwartz, Megan J., Warren, Derek T., Hayward, Robert, Lin, Ziyuan, Zhang, Lin, Morris, Glenn E., McNally, Elizabeth M., Shackleton, Sue, Rao, Li, Shanahan, Catherine M., Zhang, Qiuping
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458344/
https://ncbi.nlm.nih.gov/pubmed/28398466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx116
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