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Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis
Knudson [Knudson, A. G. (1971) Proc. Natl. Acad. Sci. USA 68, 820–823] suggested that progression of retinoblastoma follows from two mutational events. Individuals who inherit one mutated gene copy should follow an age-onset pattern set by only a single rate-limiting step for transformation, whereas...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autor principal: | |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545832/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15657129/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0407299102 |
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