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Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis
Knudson [Knudson, A. G. (1971) Proc. Natl. Acad. Sci. USA 68, 820–823] suggested that progression of retinoblastoma follows from two mutational events. Individuals who inherit one mutated gene copy should follow an age-onset pattern set by only a single rate-limiting step for transformation, whereas...
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| Natura: | Artigo |
| Lingua: | Inglês |
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National Academy of Sciences
2005
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545832/ https://ncbi.nlm.nih.gov/pubmed/15657129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407299102 |
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