Serotonergic system antagonists target breast tumor initiating cells and synergize with chemotherapy to shrink human breast tumor xenografts

Breast tumors comprise an infrequent tumor cell population, termed breast tumor initiating cells (BTIC), which sustain tumor growth, seed metastases and resist cytotoxic therapies. Hence therapies are needed to target BTIC to provide more durable breast cancer remissions than are currently achieved....

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Gwynne, William D, Hallett, Robin M, Girgis-Gabardo, Adele, Bojovic, Bojana, Dvorkin-Gheva, Anna, Aarts, Craig, Dias, Kay, Bane, Anita, Hassell, John A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458271/
https://ncbi.nlm.nih.gov/pubmed/28404880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16646
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