Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast

We have previously found that exogenously added lithocholic acid delays yeast chronological aging. We demonstrated that lithocholic acid enters the yeast cell, is sorted to mitochondria, resides in both mitochondrial membranes, changes the relative concentrations of different membrane phospholipids,...

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發表在:Oncotarget
Main Authors: Leonov, Anna, Arlia-Ciommo, Anthony, Bourque, Simon D., Koupaki, Olivia, Kyryakov, Pavlo, Dakik, Pam鼳la, McAuley, M鼳lissa, Medkour, Younes, Mohammad, Karamat, Maulo, Tamara Di, Titorenko, Vladimir I.
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2017
主題:
Research Paper: Gerotarget (Focus on Aging)
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458158/
https://ncbi.nlm.nih.gov/pubmed/28410198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16766
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