Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast

We have previously found that exogenously added lithocholic acid delays yeast chronological aging. We demonstrated that lithocholic acid enters the yeast cell, is sorted to mitochondria, resides in both mitochondrial membranes, changes the relative concentrations of different membrane phospholipids,...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Leonov, Anna, Arlia-Ciommo, Anthony, Bourque, Simon D., Koupaki, Olivia, Kyryakov, Pavlo, Dakik, Pam鼳la, McAuley, M鼳lissa, Medkour, Younes, Mohammad, Karamat, Maulo, Tamara Di, Titorenko, Vladimir I.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2017
Sujets:
Research Paper: Gerotarget (Focus on Aging)
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458158/
https://ncbi.nlm.nih.gov/pubmed/28410198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16766
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