Short single-stranded DNA degradation products augment the activation of Toll-like receptor 9

Toll-like receptors encounter a diversity of degradation products in endosomes. TLR7 and TLR8 have been shown to be activated by RNA degradation products. Here we show that although TLR9 requires single-stranded DNA longer than 20 nucleotides for a robust response, TLR9 activation is augmented by Cp...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Pohar, Jelka, Lainšček, Duško, Ivičak-Kocjan, Karolina, Cajnko, Miša-Mojca, Jerala, Roman, Benčina, Mojca
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458134/
https://ncbi.nlm.nih.gov/pubmed/28530246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15363
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