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MONKEY: identifying conserved transcription-factor binding sites in multiple alignments using a binding site-specific evolutionary model

We introduce a method (MONKEY) to identify conserved transcription-factor binding sites in multispecies alignments. MONKEY employs probabilistic models of factor specificity and binding-site evolution, on which basis we compute the likelihood that putative sites are conserved and assign statistical...

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Published in:Genome Biol
Main Authors: Moses, Alan M, Chiang, Derek Y, Pollard, Daniel A, Iyer, Venky N, Eisen, Michael B
Format: Artigo
Language:Inglês
Published: BMC 2004
Subjects:
Method
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC545801/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15575972/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/gb-2004-5-12-r98
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