Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

BACKGROUND: Multiple studies concluded that oncometabolites (e.g. D-2-hydroxyglutarate (2-HG) related to mutant isocitrate dehydrogenase 1/2 (IDH1/2) and lactate) have tumour promoting potential. Regulatory mechanisms implicated in the maintenance of oncometabolite production have great interest. mT...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Hujber, Zoltán, Petővári, Gábor, Szoboszlai, Norbert, Dankó, Titanilla, Nagy, Noémi, Kriston, Csilla, Krencz, Ildikó, Paku, Sándor, Ozohanics, Olivér, Drahos, László, Jeney, András, Sebestyén, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457553/
https://ncbi.nlm.nih.gov/pubmed/28578659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0544-y
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