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Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity

The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we ide...

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Podrobná bibliografie
Vydáno v:	Sci Rep
Hlavní autoři:	Sagar, Divya, Singh, Narendra P., Ginwala, Rashida, Huang, Xiaofang, Philip, Ramila, Nagarkatti, Mitzi, Nagarkatti, Prakash, Neumann, Konstantin, Ruland, Jürgen, Andrews, Allison M., Ramirez, Servio H., Khan, Zafar K., Jain, Pooja
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group UK 2017
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5457463/ https://ncbi.nlm.nih.gov/pubmed/28578388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03027-x
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Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity

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