Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity

The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we ide...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Sagar, Divya, Singh, Narendra P., Ginwala, Rashida, Huang, Xiaofang, Philip, Ramila, Nagarkatti, Mitzi, Nagarkatti, Prakash, Neumann, Konstantin, Ruland, Jürgen, Andrews, Allison M., Ramirez, Servio H., Khan, Zafar K., Jain, Pooja
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457463/
https://ncbi.nlm.nih.gov/pubmed/28578388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03027-x
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