Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity

The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we ide...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Sagar, Divya, Singh, Narendra P., Ginwala, Rashida, Huang, Xiaofang, Philip, Ramila, Nagarkatti, Mitzi, Nagarkatti, Prakash, Neumann, Konstantin, Ruland, Jürgen, Andrews, Allison M., Ramirez, Servio H., Khan, Zafar K., Jain, Pooja
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457463/
https://ncbi.nlm.nih.gov/pubmed/28578388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03027-x
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