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Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide

Glucocorticoids have been used to treat hearing loss and vestibular dysfunction for many years. However, some reports have indicated that a subset of patients with these disorders exhibit glucocorticoid insensitivity or resistance. A reduction in histone deacetylase 2 (HDAC2) activity and expression...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhou, Qiong-Qiong, Dai, Yan-Hong, Du, Xiao-Ping, Hou, Jie, Qi, Hui, She, Wan-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457401/
https://ncbi.nlm.nih.gov/pubmed/28578424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02956-x
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