FAS-associated factor-1 positively regulates type I interferon response to RNA virus infection by targeting NLRX1

FAS-associated factor-1 (FAF1) is a component of the death-inducing signaling complex involved in Fas-mediated apoptosis. It regulates NF-κB activity, ubiquitination, and proteasomal degradation. Here, we found that FAF1 positively regulates the type I interferon pathway. FAF1(gt/gt) mice, which def...

詳細記述

保存先:
書誌詳細
出版年:PLoS Pathog
主要な著者: Kim, Jae-Hoon, Park, Min-Eun, Nikapitiya, Chamilani, Kim, Tae-Hwan, Uddin, Md Bashir, Lee, Hyun-Cheol, Kim, Eunhee, Ma, Jin Yeul, Jung, Jae U., Kim, Chul-Joong, Lee, Jong-Soo
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2017
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5456407/
https://ncbi.nlm.nih.gov/pubmed/28542569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006398
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