Mutations in PA2491 (mexS) Promote MexT-Dependent mexEF-oprN Expression and Multidrug Resistance in a Clinical Strain of Pseudomonas aeruginosa

Disruption of the PA2491 gene in a mini-Tn5-tet insertion mutant of a clinical isolate of Pseudomonas aeruginosa increased expression of the mexEF-oprN multidrug efflux genes and decreased production of outer membrane protein OprD, concomitant with enhanced resistance to chloramphenicol, quinolones,...

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Bibliographic Details
Main Authors: Sobel, Mara L., Neshat, Shadi, Poole, Keith
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Molecular Biology of Pathogens
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC545639/
https://ncbi.nlm.nih.gov/pubmed/15687188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.187.4.1246-1253.2005
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