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Notch-1 activation and dendritic atrophy in prion disease

In addition to neuronal vacuolation and astrocytic hypertrophy, dendritic atrophy is a prominent feature of prion disease. Because increased Notch-1 expression and cleavage releasing its intracellular domain (NICD) inhibit both dendrite growth and maturation, we measured their levels in brains from...

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Bibliografische gegevens
Hoofdauteurs: Ishikura, Nako, Clever, Jared L., Bouzamondo-Bernstein, Essia, Samayoa, Erik, Prusiner, Stanley B., Huang, Eric J., DeArmond, Stephen J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2005
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545568/
https://ncbi.nlm.nih.gov/pubmed/15640354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408612101
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