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Notch-1 activation and dendritic atrophy in prion disease
In addition to neuronal vacuolation and astrocytic hypertrophy, dendritic atrophy is a prominent feature of prion disease. Because increased Notch-1 expression and cleavage releasing its intracellular domain (NICD) inhibit both dendrite growth and maturation, we measured their levels in brains from...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545568/ https://ncbi.nlm.nih.gov/pubmed/15640354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408612101 |
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