Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4

The generation of hematopoietic stem cells from human pluripotent stem cells (hPSCs) is a major goal for regenerative medicine. Achieving this goal is complicated by our incomplete understanding of the mechanism regulating definitive hematopoietic specification. We used our stage-specific hPSC diffe...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Creamer, J. Philip, Dege, Carissa, Ren, Qihao, Ho, Jolie T. K., Valentine, Mark C., Druley, Todd E., Sturgeon, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Hematopoiesis And Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454336/
https://ncbi.nlm.nih.gov/pubmed/28408465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-749382
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