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Evidence for shear-mediated Ca(2+) entry through mechanosensitive cation channels in human platelets and a megakaryocytic cell line

The role of mechanosensitive (MS) Ca(2+)-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. We therefore sought to investigate the expression and functional relevance of MS channels in human platelets....

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ilkan, Zeki, Wright, Joy R., Goodall, Alison H., Gibbins, Jonathan M., Jones, Chris I., Mahaut-Smith, Martyn P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454102/
https://ncbi.nlm.nih.gov/pubmed/28416610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766196
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