Kv1.3 is the exclusive voltage-gated K(+) channel of platelets and megakaryocytes: roles in membrane potential, Ca(2+) signalling and platelet count

A delayed rectifier voltage-gated K(+) channel (Kv) represents the largest ionic conductance of platelets and megakaryocytes, but is undefined at the molecular level. Quantitative RT-PCR of all known Kv α and ancillary subunits showed that only Kv1.3 (KCNA3) is substantially expressed in human plate...

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Detalhes bibliográficos
Main Authors: McCloskey, Conor, Jones, Sarah, Amisten, Stefan, Snowden, Roger T, Kaczmarek, Leonard K, Erlinge, David, Goodall, Alison H, Forsythe, Ian D, Mahaut-Smith, Martyn P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Molecular and Cellular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876798/
https://ncbi.nlm.nih.gov/pubmed/20308249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.188136
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