Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease

Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise involvement of elevated NAA in the pathogenesis of Canavan disease is an ongoing debate. In the present study, we tested the effects of elevated NAA...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Appu, Abhilash P., Moffett, John R., Arun, Peethambaran, Moran, Sean, Nambiar, Vikram, Krishnan, Jishnu K. S., Puthillathu, Narayanan, Namboodiri, Aryan M. A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454052/
https://ncbi.nlm.nih.gov/pubmed/28626388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2017.00161
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