A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

The JAK2/STAT3 signaling pathway plays a critical role in tumorigenesis, and has been suggested as a potential molecular target for anti-melanoma therapeutics. However, few JAK2 inhibitors were being tested for melanoma therapy. In this study, eight amentoflavone analogues were evaluated for their a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wu, Ke-Jia, Huang, Jie-Min, Zhong, Hai-Jing, Dong, Zhen-Zhen, Vellaisamy, Kasipandi, Lu, Jin-Jian, Chen, Xiu-Ping, Chiu, Pauline, Kwong, Daniel W. J., Han, Quan-Bin, Ma, Dik-Lung, Leung, Chung-Hang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453690/
https://ncbi.nlm.nih.gov/pubmed/28570563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177123
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