Evaluation of [(18)F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood–brain barrier in rats: Kinetics, metabolism, and selectivity

P-glycoprotein is a protective efflux transporter at the blood–brain barrier showing altered function in many neurological disorders. The purpose of this study was to validate [(18)F]MC225 as a radiotracer for measuring P-glycoprotein function with positron emission tomography. Three groups of Sprag...

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Vydáno v:J Cereb Blood Flow Metab
Hlavní autoři: Savolainen, Heli, Windhorst, Albert D, Elsinga, Philip H, Cantore, Mariangela, Colabufo, Nicola A, Willemsen, Antoon TM, Luurtsema, Gert
Médium: Artigo
Jazyk:Inglês
Vydáno: SAGE Publications 2016
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453451/
https://ncbi.nlm.nih.gov/pubmed/27354093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X16654493
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