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OXIDATIVE STRESS DURING DIABETIC PREGNANCY DISRUPTS CARDIAC NEURAL CREST MIGRATION AND CAUSES OUTFLOW TRACT DEFECTS
BACKGROUND: Maternal diabetes increases risk for congenital malformations, particularly cardiac outflow tract defects. Maternal diabetes inhibits expression of Pax3 in neuroepithelium through hyperglycemia-induced oxidative stress. The neuroepithelium gives rise to the neural crest, and Pax3 express...
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| Publicado no: | Birth Defects Res A Clin Mol Teratol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5452612/ https://ncbi.nlm.nih.gov/pubmed/18435457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdra.20457 |
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