Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis

BACKGROUND: Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previou...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Aldrich, Melissa B., Velasquez, Fred C., Kwon, Sunkuk, Azhdarinia, Ali, Pinkston, Kenneth, Harvey, Barrett R., Chan, Wenyaw, Rasmussen, John C., Ross, Russell F., Fife, Caroline E., Sevick-Muraca, E. M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452411/
https://ncbi.nlm.nih.gov/pubmed/28566090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1323-z
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