Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis

BACKGROUND: Evidence suggests lymphatic function mediates local rheumatoid arthritis (RA) flares. Yet biologics that target the immune system are dosed systemically via the subcutaneous (SC) administration route, thereby inefficiently reaching local lymphatic compartments. Nanotopography has previou...

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Bibliografiske detaljer
Udgivet i:Arthritis Res Ther
Main Authors: Aldrich, Melissa B., Velasquez, Fred C., Kwon, Sunkuk, Azhdarinia, Ali, Pinkston, Kenneth, Harvey, Barrett R., Chan, Wenyaw, Rasmussen, John C., Ross, Russell F., Fife, Caroline E., Sevick-Muraca, E. M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452411/
https://ncbi.nlm.nih.gov/pubmed/28566090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1323-z
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