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In-vivo monitoring of anti-folate therapy in arthritic rats using [(18)F]fluoro-PEG-folate and positron emission tomography

BACKGROUND: Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is expressed on synovial macrophages and recently has been explored as a biomarker for imaging in arthritic rats using the folate-bas...

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Détails bibliographiques
Publié dans:Arthritis Res Ther
Auteurs principaux: Chandrupatla, Durga M. S. H., Jansen, Gerrit, Vos, Ricardo, Verlaan, Mariska, Chen, Qingshou, Low, Philip S., Windhorst, Albert D., Lammertsma, Adriaan A., van der Laken, Conny J., Molthoff, Carla F. M.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5452381/
https://ncbi.nlm.nih.gov/pubmed/28569209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1325-x
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