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Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides
We report a strategy for efficient post-translational modification of a library of ribosomally-translated peptides by activation and elimination of cysteine to dehydroalanine then conjugate addition of a range of exogenous thiols, with an emphasis on carbohydrates. These reactions are selective for...
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| Опубликовано в: : | Chem Sci |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Royal Society of Chemistry
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5452274/ https://ncbi.nlm.nih.gov/pubmed/28572907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc04381j |
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