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Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis

Glomerular hypertension and hyperfiltration in early diabetes are associated with development and progression of diabetic kidney disease. The tubular hypothesis of diabetic hyperfiltration proposes that it is initiated by a primary increase in sodium (Na) reabsorption in the proximal tubule (PT) and...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Hallow, K. Melissa, Gebremichael, Yeshitila, Helmlinger, Gabriel, Vallon, Volker
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451553/
https://ncbi.nlm.nih.gov/pubmed/28148531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00497.2016
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