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Primary proximal tubule hyperreabsorption and impaired tubular transport counterregulation determine glomerular hyperfiltration in diabetes: a modeling analysis

Glomerular hypertension and hyperfiltration in early diabetes are associated with development and progression of diabetic kidney disease. The tubular hypothesis of diabetic hyperfiltration proposes that it is initiated by a primary increase in sodium (Na) reabsorption in the proximal tubule (PT) and...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Renal Physiol
Hoofdauteurs: Hallow, K. Melissa, Gebremichael, Yeshitila, Helmlinger, Gabriel, Vallon, Volker
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451553/
https://ncbi.nlm.nih.gov/pubmed/28148531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00497.2016
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