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Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
Arginase-1 deficiency in humans is a rare genetic disorder of metabolism resulting from a loss of arginase-1, leading to impaired ureagenesis, hyperargininemia and neurological deficits. Previously, we generated a tamoxifen-inducible arginase-1 deficient mouse model harboring a deletion of Arg1 exon...
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Publicat a: | Sci Rep |
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Autors principals: | , , , |
Format: | Artigo |
Idioma: | Inglês |
Publicat: |
Nature Publishing Group UK
2017
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5451454/ https://ncbi.nlm.nih.gov/pubmed/28566761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02927-2 |
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