Ca(2+) channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Loss of first-phase insulin secretion is an early sign of developing type 2 diabetes (T2D). Ca(2+) entry through voltage-gated L-type Ca(2+) channels triggers exocytosis of insulin-containing granules in pancreatic β cells and is required for the postprandial spike in insulin secretion. Using high-r...

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Pubblicato in:J Clin Invest
Autori principali: Gandasi, Nikhil R., Yin, Peng, Riz, Michela, Chibalina, Margarita V., Cortese, Giuliana, Lund, Per-Eric, Matveev, Victor, Rorsman, Patrik, Sherman, Arthur, Pedersen, Morten G., Barg, Sebastian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451232/
https://ncbi.nlm.nih.gov/pubmed/28481223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88491
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