Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors

Therapies using T cells that are programmed to express chimeric antigen receptors (CAR T cells) consistently produce positive results in patients with hematologic malignancies. However, CAR T cell treatments are less effective in solid tumors for several reasons. First, lymphocytes do not efficientl...

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Библиографические подробности
Опубликовано в: :J Clin Invest
Главные авторы: Smith, Tyrel T., Moffett, Howell F., Stephan, Sirkka B., Opel, Cary F., Dumigan, Amy G., Jiang, Xiuyun, Pillarisetty, Venu G., Pillai, Smitha P. S., Wittrup, K. Dane, Stephan, Matthias T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451231/
https://ncbi.nlm.nih.gov/pubmed/28436934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87624
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