Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition

OBJECTIVES: Sarcopenia refers to the involuntary loss of skeletal muscle and is a predictor of physical disability/mortality. Its pathogenesis is poorly understood, although roles for altered hypoxic signaling, oxidative stress, adipokines and inflammatory mediators have been suggested. Sarcopenia a...

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Vydáno v:Redox Biol
Hlavní autoři: Wandrag, Liesl, Siervo, Mario, Riley, Heather L., Khosravi, Maryam, Fernandez, Bernadette O., Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Stroud, Michael A., Grocott, Michael P.W., Feelisch, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451185/
https://ncbi.nlm.nih.gov/pubmed/28570949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.004
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