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Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition

OBJECTIVES: Sarcopenia refers to the involuntary loss of skeletal muscle and is a predictor of physical disability/mortality. Its pathogenesis is poorly understood, although roles for altered hypoxic signaling, oxidative stress, adipokines and inflammatory mediators have been suggested. Sarcopenia a...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Wandrag, Liesl, Siervo, Mario, Riley, Heather L., Khosravi, Maryam, Fernandez, Bernadette O., Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Stroud, Michael A., Grocott, Michael P.W., Feelisch, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451185/
https://ncbi.nlm.nih.gov/pubmed/28570949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.004
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