Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition

OBJECTIVES: Sarcopenia refers to the involuntary loss of skeletal muscle and is a predictor of physical disability/mortality. Its pathogenesis is poorly understood, although roles for altered hypoxic signaling, oxidative stress, adipokines and inflammatory mediators have been suggested. Sarcopenia a...

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保存先:
書誌詳細
出版年:Redox Biol
主要な著者: Wandrag, Liesl, Siervo, Mario, Riley, Heather L., Khosravi, Maryam, Fernandez, Bernadette O., Leckstrom, Carl A., Martin, Daniel S., Mitchell, Kay, Levett, Denny Z.H., Montgomery, Hugh E., Mythen, Monty G., Stroud, Michael A., Grocott, Michael P.W., Feelisch, Martin
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2017
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451185/
https://ncbi.nlm.nih.gov/pubmed/28570949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.05.004
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