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Structured states of disordered proteins from genomic sequences

Protein flexibility ranges from simple hinge movements to functional disorder. Around half of all human proteins contain apparently disordered regions, with little 3D or functional information, and many of these proteins are associated with disease. Building on the evolutionary couplings approach pr...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Toth-Petroczy, Agnes, Palmedo, Perry, Ingraham, John, Hopf, Thomas A., Berger, Bonnie, Sander, Chris, Marks, Debora S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5451116/
https://ncbi.nlm.nih.gov/pubmed/27662088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.010
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