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3D structures of membrane proteins from genomic sequencing
We show that amino acid co-variation in proteins, extracted from the evolutionary sequence record, can be used to fold transmembrane proteins. We use this technique to predict previously unknown, 3D structures for 11 transmembrane proteins (with up to 14 helices) from their sequences alone. The pred...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3641781/ https://ncbi.nlm.nih.gov/pubmed/22579045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.04.012 |
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