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Connecting Bone and Fat: The Potential Role for Sclerostin
Sclerostin (SOST), a protein secreted from mature osteocytes in response to mechanical unloading and other stimuli, inhibits the osteogenic Wnt/β-catenin pathway in mesenchymal stem cells (MSCs) impeding their ability to differentiate into mineralizing osteoblasts. PURPOSE: This review summarizes th...
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| Publié dans: | Curr Mol Biol Rep |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5448707/ https://ncbi.nlm.nih.gov/pubmed/28580233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40610-017-0057-7 |
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