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Hsp104 disaggregase at normal levels cures many [PSI(+)] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p
Overproduction or deficiency of many chaperones and other cellular components cure the yeast prions [PSI(+)] (formed by Sup35p) or [URE3] (based on Ure2p). However, at normal expression levels, Btn2p and Cur1p eliminate most newly arising [URE3] variants but do not cure [PSI(+)], even after overexpr...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5448221/ https://ncbi.nlm.nih.gov/pubmed/28484020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704016114 |
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