Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases

Product template (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for controlling the aldol cyclizations of poly-β-ketone intermediates assembled during the catalytic cycle. Our ability to understand the high regioselective control that PT domains exert is hindered...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Barajas, Jesus F., Shakya, Gaurav, Moreno, Gabriel, Rivera, Heriberto, Jackson, David R., Topper, Caitlyn L., Vagstad, Anna L., La Clair, James J., Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448209/
https://ncbi.nlm.nih.gov/pubmed/28484029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609001114
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