STRUCTURAL AND BIOCHEMICAL ANALYSIS OF PROTEIN-PROTEIN INTERACTIONS BETWEEN THE ACYL-CARRIER PROTEIN AND PRODUCT TEMPLATE DOMAIN

In fungal non-reducing polyketide synthases (NR-PKS), the acyl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elongation, cyclization and product release. This process occurs through a controlled, yet enigmatic coordination of the ACP with its partner e...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Barajas, Jesus F., Finzel, Kara, Valentic, Timothy R., Shakya, Gaurav, Gamarra, Nathan, Martinez, Delsy, Meier, Jordan L., Vagstad, Anna L., Newman, Adam G., Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161458/
https://ncbi.nlm.nih.gov/pubmed/27653519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201605401
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