Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism

Effective control of endotoxins and bacteria is crucial for normal wound healing. During injury, the key enzyme thrombin is formed, leading to generation of fibrin. Here, we show that human neutrophil elastase cleaves thrombin, generating 11-kDa thrombin-derived C-terminal peptides (TCPs), which bin...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Petrlova, Jitka, Hansen, Finja C., van der Plas, Mariena J. A., Huber, Roland G., Mörgelin, Matthias, Malmsten, Martin, Bond, Peter J., Schmidtchen, Artur
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448181/
https://ncbi.nlm.nih.gov/pubmed/28473418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619609114
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