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Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism
Effective control of endotoxins and bacteria is crucial for normal wound healing. During injury, the key enzyme thrombin is formed, leading to generation of fibrin. Here, we show that human neutrophil elastase cleaves thrombin, generating 11-kDa thrombin-derived C-terminal peptides (TCPs), which bin...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5448181/ https://ncbi.nlm.nih.gov/pubmed/28473418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619609114 |
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