Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

Symbiotic microbes impact the severity of a variety of diseases through regulation of T-cell development. However, little is known regarding the molecular mechanisms by which this is accomplished. Here we report that a secreted factor, Erdr1, is regulated by the microbiota to control T-cell apoptosi...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Soto, Raymond, Petersen, Charisse, Novis, Camille L., Kubinak, Jason L., Bell, Rickesha, Stephens, W. Zac, Lane, Thomas E., Fujinami, Robert S., Bosque, Alberto, O’Connell, Ryan M., Round, June L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5448176/
https://ncbi.nlm.nih.gov/pubmed/28487480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619336114
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